Understanding DNA,
Edition 3 The Molecule and How it WorksEditors: By Chris R. Calladine, Horace Drew, Ben Luisi and Andrew Travers
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Description
The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth.
The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication.
Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA.
Key Features
- Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix
- Outlines the methods used to study DNA structure
- Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension
About the author
By Chris R. Calladine, Dept. of Engineering, University of Cambridge, U.K.; Horace Drew, CSIRO Division of Biotechnology, Sydney, Australia; Ben Luisi, Department of Biochemistry, University of Cambridge, U.K. and Andrew Travers, MRC Laboratory of Molecular Biology, University of Cambridge, U.K.
An Introduction to Molecular Biology for Non-Scientists
Why a Helix?
Different Kinds of Double Helix
Twisting and Curving
Curving in Three Dimensions
DNA Supercoiling
The Assembly of DNA intor Chromosomes
Specific DNA-Protein Interactions
Methods Used to Study the Structure of DNA
DNA in Disease, Diagnostics and Medicine
Cytosine Methylation and DNA Epigenetics
Appendix
1: Notes on the Derivation of Some Technical Terms
2: The Chemical Theory of Base-stacking Interactions in DNA
3: How to modify Gene Expression by means of Anti-sense Oligonucleotides, Ribozymes or si-RNA
Title Reviews
Praise for previous editions:
"Stylish...beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit and which will also generate a refreshing perspective for experts"—NATURE
"Understanding DNA is a great book that will surely prove to be a valuable teaching tool."—THE BIOCHEMIST
"A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective."—TRENDS IN GENETICS
Wolffe:CHROMATIN, 3E (1999, 41.95 USD/ 28.95 GBP, ISBN: 0127619151)