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Book Details
Key Features
- Describes the origin and molecular biology of pandemic influenza, HIV1, and HIV2 as well as the recent work on papillomaviruses, herpesviruses, BSE, and variant CJD
- Contains the latest data on tuberculosis, microbial evasion of immune defenses, and the spread of antibiotic resistance genes among bacteria
- Provides an update on vaccines, prions, immune evasion, and microbial ligands and receptors
- Gives an up-to-date picture of the global burden of infectious diseases
About the author
By Anthony A. Nash, University of Edinburgh, UK; Robert G. Dalziel, University of Edinburgh, UK and J. Ross Fitzgerald, University of Edinburgh, UK- Preface
- Chapter 1. General Principles
- Bibliography
- Chapter 2. Attachment to and Entry of Microorganisms into the Body
- Introduction
- Adhesion/Entry: Some General Considerations
- The Skin
- Respiratory Tract
- Gastrointestinal Tract
- Oropharynx
- Urinogenital Tract
- Conjunctiva
- The Normal Microbiota
- Exit of Microorganisms from the Body
- Bibliography
- Chapter 3. Early Stages of Infection After Pathogen Entry
- Growth in Epithelial Cells
- Intracellular Microorganisms and Spread Through the Body
- Subepithelial Invasion
- Nutritional Requirements of Invading Microbes
- Bibliography
- Chapter 4. Encounter of Microbes with Phagocytic Cells
- Cell Biology of Phagocytosis
- Phagocytosis in Polymorphonuclear Leucocytes
- Phagocytosis in Macrophages
- Microbial Strategy in Relation to Phagocytes
- Growth in the Phagocytic Cell
- Killing the Phagocyte
- Entry into the Host Cell Other Than by Phagocytosis
- Consequences of Defects in the Phagocytic Cell
- Summary
- Bibliography
- Chapter 5. The Spread of Microbes Through the Body
- Direct Spread
- Microbial Factors Promoting Spread
- Spread Via Lymphatics
- Spread Via the Blood
- Spread Via Other Pathways
- Bibliography
- Chapter 6. The Immune Response to Infection
- Antibody Response
- T-Cell-Mediated Immune Response
- NK Cells
- Macrophages, Neutrophils and Mast Cells
- Complement and Related Defence Molecules
- Conclusions Concerning the Immune Response to Microorganisms
- Bibliography
- Chapter 7. Microbial Strategies in Relation to the Immune Response
- Induction of Immunological Tolerance
- Immunosuppression
- Absence of a Suitable Target for the Immune Response
- Microbial Presence in Bodily Sites Inaccessible to the Immune Response
- Induction of Inappropriate Antibody and T-Cell Responses
- Antibodies Mopped up by Soluble Microbial Antigens
- Local Interference with Immune Forces
- Reduced Interferon Induction or Responsiveness
- Antigenic Variation
- Bibliography
- Chapter 8. Mechanisms of Cell and Tissue Damage
- Infection with No Cell or Tissue Damage
- Direct Damage by Microorganisms
- Microbial Toxins
- Indirect Damage via Inflammation
- Indirect Damage via the Immune Response (Immunopathology)
- Other Indirect Mechanisms of Damage
- Diarrhoea
- Bibliography
- Chapter 9. Recovery from Infection
- Immunological Factors in Recovery
- Inflammation
- Complement
- Interferons
- Multimechanistic Recovery: An Example
- Temperature
- Tissue Repair
- Resistance to Re-Infection
- Bibliography
- Chapter 10. Failure to Eliminate Microbe
- Latency
- Persistent Infection with Shedding
- Epidemiological Significance of Persistent Infection with Shedding
- Persistent Infection Without Shedding
- Significance for the Individual of Persistent Infections
- Conclusions
- Bibliography
- Chapter 11. Host and Microbial Factors Influencing Susceptibility
- Genetic Factors in the Microorganism
- Genetic Factors in the Host
- Stress and Hormonal Factors
- Other Factors
- Bibliography
- Chapter 12. Vaccines and How They Work
- Introduction
- General Principles
- Complications and Side Effects of Vaccines
- Reverse Vaccinology
- Bibliography
- Appendix
- Conclusions
- Glossary
- Index
Title Reviews
"It is a valuable asset for all healthcare students, course directors, and officials who require critical knowledge about how microorganisms initiate and, in some cases, perpetuate human infections. Score: 78 - 3 Stars"—Doody's
Praise for the previous edition: "This book should be in every medical library..."—POSTGRADUATE MEDICAL JOURNAL"This is an outstanding book of high scholarship of much interest to immunologists, microbiologists, pathologists and all those concerned with infectious diseases."—MOLECULAR MEDICINE TODAY"A splendidly imaginative book which will become a trusty companion for many of us."—THE LANCET"A short but comprehensive description of the mechanisms of infectious disease in an eminently readable form suitable for undergraduates in medicine, veterinary medicine and microbiology. An excellent book which should be read by teachers, students and research workers."—NEW SCIENTIST"In bringing this material together clearly, in one short thoughtful volume, Professor Mims offers the student a chance to acquire a sound appreciation of the infectious process."—BRITISH MEDICAL JOURNAL"It remains excellent value for money and will I am sure long continue to be a standard text."—JOURNAL OF MEDICAL MICROBIOLOGY"Clear, well-written text including tables, and impressive schematic drawings."—EXPERIMENTAL PATHOLOGY
- Krause, Emerging Infections, 1999, 9780124259300, $99.95
- White, Medical Virology, 4e, 1994, 9780127466422, $72.95












