Abbreviations
Online Study Guide
Preface
The Academic Cell Approach
Introduction to the Online Study Guide
Biographies: Authors
Contributors
Acknowledgments
Part I: Basic Immunology
Chapter 1. Introduction to the Immune Response
Abstract
A Historical Orientation
B The Nature of the Immune Response
C Types of Immune Responses: Innate and Adaptive
D Interplay between the Innate and Adaptive Responses
E Clinical Immunology
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Chapter 2. Components of the Immune System
Abstract
A Cells of the Immune System
B How Leukocytes Communicate
C Lymphoid Tissues
D Cellular Movement in the Immune System
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Chapter 3. Innate Immunity
Abstract
A Non-Inducible Innate Mechanisms
B Inducible Innate Mechanisms
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Chapter 4. The B Cell Receptor: Proteins and Genes
Abstract
A Immunoglobulin Proteins
B Immunoglobulin Genes
C Antibody–Antigen Interaction
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Chapter 5. B Cell Development, Activation and Effector Functions
Abstract
A B Cell Development: Maturation Phase
B B Cell Development: Differentiation Phase
C Effector Functions of Antibodies
D Immunoglobulin Isotypes in Biological Context
E Sources of Laboratory and Clinical Antibodies
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Chapter 6. The Major Histocompatibility Complex
Abstract
A Overview of the Major Histocompatibility Complex
B MHC Class I and Class II Proteins
C MHC Class I and Class II Genes
D Physiology of the MHC
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Chapter 7. Antigen Processing and Presentation
Abstract
A Overview of Antigen Processing and Presentation
B Nature of Cells That Can Activate T Cells
C Major Antigen Processing and Presentation Pathways
D Other Methods of Antigen Presentation
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Chapter 8. The T Cell Receptor: Proteins and Genes
Abstract
A TCR Proteins and Associated Molecules
B TCR Genes
C TCR–Antigen Interaction
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Chapter 9. T Cell Development, Activation and Effector Functions
Abstract
A T Cell Development
B T Cell Activation
C Th Cell Differentiation and Effector Function
D Tc Cell Differentiation and Effector Function
E Termination of Effector T Cell Responses
F Memory T Cells
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Chapter 10. Regulation of Immune Responses in the Periphery
Abstract
A Lymphocyte Tolerance in the Periphery
B Regulation of Lymphocyte Responses in the Periphery
C Special Tolerance Situations
D Experimental Tolerance
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Chapter 11. NK, γδ T and NKT Cells
Abstract
A Natural Killer (NK) Cells
B γδ T Cells
C NKT Cells
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Chapter 12. Mucosal and Cutaneous Immunity
Abstract
A Mucosal Immunity
B Cutaneous Immunity
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Part II: Clinical Immunology
Chapter 13. Immunity to Infection
Abstract
A General Features of Host–Pathogen Encounters
B Immunity to Extracellular Bacteria
C Immunity to Intracellular Bacteria
D Immunity to Viruses
E Immunity to Parasites
F Immunity to Fungi
G Prions
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Chapter 14. Vaccination
Abstract
A Introduction
B Vaccine Design
C Types of Vaccines
D Adjuvants and Delivery Vehicles
E Prophylactic Vaccines
F Vaccines in the Real World
G Future Directions
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Chapter 15. Immunodeficiency
Abstract
A Primary Immunodeficiency
B HIV Infection and Acquired Immunodeficiency Syndrome (AIDS)
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Chapter 16. Tumor Immunology
Abstract
A Tumor Biology
B Tumor Antigens
C Immune System Function in the Tumor Microenvironment
D Conventional Cancer Therapy
E Immunotherapy
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Chapter 17. Transplantation
Abstract
A The Nature of Transplantation
B The Molecular Basis of Graft Rejection
C Solid Organ Transplantation
D Minimizing Graft Rejection
E Hematopoietic Stem Cell Transplantation
F Blood Transfusions
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Chapter 18. Immune Hypersensitivity
Abstract
A Type I Hypersensitivity: IgE-Mediated or Immediate
B Type II Hypersensitivity: Direct Antibody-Mediated Cytotoxic Hypersensitivity
C Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity
D Type IV Hypersensitivity: Delayed Type or Cell-Mediated Hypersensitivity
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Chapter 19. Autoimmune Diseases
Abstract
A What is an Autoimmune Disease?
B Mechanisms Underlying Autoimmune Diseases
C Examples of Autoimmune Diseases
D Determinants of Autoimmune Diseases
E Therapy of Autoimmune Diseases
F Autoinflammatory Disorders
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Chapter 20. Hematopoietic Cancers
Abstract
A Overview of the Biology and Treatment of Hematopoietic Cancers
B Leukemias
C Myelomas
D Lymphomas
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Appendix A. Selected Landmark Discoveries in Immunology
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Appendix B. Nobel Prizes Awarded for Work in Immunology
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Appendix C. Comparative Immunology
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Appendix D. Selected CD Markers
Appendix E. Cytokines, Chemokines and Receptors
Appendix F. Selected Immunological Techniques
I Experimental Techniques Using Antibodies
II The Polymerase Chain Reaction
III HLA Typing Techniques
IV Laboratory Mouse Strains
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Glossary
Index
