Organic Laboratory Experiments of the Future - Edition 1 - By Bruce H. Lipshutz and Hubert Muchalski Elsevier Educate

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Organic Laboratory Experiments of the Future,

Edition 1 Doing Chemistry in Water

By Bruce H. Lipshutz and Hubert Muchalski

Publication Date: 19 Dec 2025

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This lab manual offers students the opportunity to learn organic chemistry through a green chemistry lens, resulting in a more sustainable, future-looking course. Lipshutz and Muchalski’s Organic Laboratory Experiments of the Future: Doing Chemistry in Water approaches the subject with experiments, diagrams, and illustrations shaped by student feedback and honed through years of research and laboratory experience.

Organic Laboratory Experiments of the Future: Doing Chemistry in Water includes material on reactions run in water, including but not limited to: ppm Pd-catalyzed couplings, SNAr reactions, nitro group reductions, enzyme-catalyzed reactions, catalytic hydrogenation of olefins, olefin metathesis, reductive aminations, and chemoenzymatic sequences. This lab manual is ideal for courses in organic chemistry, biochemistry, sustainable and green chemistry, and environmentally-responsible lab courses.

Key Features

Provides practical information and techniques for utilizing green chemistry, and chemistry in water, in particular, in the study of modern organic chemistry.
Includes numerous figures, examples, illustrative problems, and appendices that reinforce laboratory concepts and methods.
Features coverage on experiments that focus on chemocatalysis as well as biocatalysis; reactions that include Nobel Prize-winning organometallic chemistry; multi-step sequences involving chemocatalysis, or chemoenzymatic catalysist

About the author

By Bruce H. Lipshutz, Distinguished Professor of Chemistry, University of California, Santa Barbara, CA, USA and Hubert Muchalski, University Professor of Chemistry, Fresno State University, Fresno, CA, USA

1. Introduction
2. Green Chemistry and Efficiency Metrics
3. Reactions in Aqueous Media
4. Surfactants
5. Laboratory Techniques for Chemistry in Water
6. Overview of Experiments
7. Experiment 1: Nitro Group Reduction Using Carbonyl Iron Powder (CIP)
8. Experiment 2: Hydrogenation of Alkenes in Water
9. Experiment 3: Nucleophilic Aromatic Substitution (SNAr)
10. Experiment 4: Amide Coupling in Water at Room Temperature
11. Experiment 5: Synthesis of Amides via 2-Pyridyl Thioester Activation
12. Experiment 6: Mild Reduction of a Carboxylic Acid to an Alcohol via 2-Pyridyl Thioester Activation
13. Experiment 7: Lipase-Catalyzed Esterification Under Aqueous Micellar Conditions
14. Experiment 8: Palladium-Catalyzed Cross-Coupling Reactions
15. Experiment 9: Investigation of the Stereochemical Outcome of a Suzuki—Miyaura Cross-Coupling in Water
16. Experiment 10: Heterogeneous Catalysis with Nanoparticles: Cross-Coupling Reactions with Low Loadings of a Pd Catalyst
17. Experiment 11: Green Synthesis of Heterocyclic Compounds
18. Experiment 12: Olefin Metathesis in Water
19. Experiment 13: Solvent-Free Diallylation of an Aryl Ethyl Ketone
20. Experiment 14: Copper-Catalyzed Click Reaction
21. Experiment 15: Gold-Catalyzed Hydration of Alkynes
22. Experiment 16: Two-Step, One-Pot Sequence: Reductive Amination
23. Experiment 17: Reductive Amination of Aldehyde Bisulfite Adducts
24. Experiment 18: Two-Step, One-Pot Sequence: Reduction and Acylation
25. Experiment 19: One-Pot Allylation / Ring-Closing Metathesis
26. Experiment 20: Preparation of Iron-/ Magnesium-Containing Nanoparticles
27. Closing remarks
Index

ISBN: 9780443239052

Page Count: 350

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Introductory college audience taking (usually simultaneously) organic chemistry, whose first organic laboratory experience is typically required; also for instructors, professionals/researchers/academics applying green chemistry and organic chemistry principles in research and applied settings, who require a manual for lab processes and experiments

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