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Bioengineering Innovative Solutions for Cancer,

Edition 1

Editors: Edited by Sylvain Ladame and Jason Chang

Publication Date: 27 Nov 2019

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Bioengineering Innovative Solutions for Cancer bridges the gap between bioengineering and cancer biology. It focuses on a ‘bottom up’ understanding of the links between molecules, cells, tissues, organs, organisms, and health and functions—all within a bioengineering context. Chapters cover the main methods, technologies and devices that could help diagnose cancer sooner (e.g., ultrasensitive imaging and sensing technologies) and helpful treatments (e.g., new, more targeted therapies). The book takes an interdisciplinary approach that is ideal for those who need the latest information on design techniques and devices that help treat cancer using new, more targeted therapies.

By covering the many different ways engineers can deliver innovative solutions to tackle cancer, this book is a valuable read for researchers who have an ambition to make an impact on people’s life in either an academic or industrial setting.

Key Features

Connects bioengineering and cancer biology, providing information on sensors, imaging, therapies and in-vitro models
Presents the most comprehensive coverage in the field of cancer engineering to date
Provides an academic introduction to (molecular) bioengineering for students, regardless of scientific background (math's, physics, chemistry, biology)
Highlights the unmet medical needs for bioengineers and the main technological breakthroughs to cancer biologists

About the author

Edited by Sylvain Ladame, Senior Lecturer, Department of Bioengineering, Imperial College London, London, UK and Jason Chang , Postdoctoral Research Associate, Koch Institute at MIT, USA

Introduction
• Chapter 1: Sensing and monitoring
o Diagnostic, prognostic and predictive biomarkers (comprehensive review of the various types of molecular biomarkers for cancer, both invasive and non-invasive. Highlighting those that have already been clinically validated and those showing great promise. Engineering/bioinformatics tools to discover and validate cancer biomarkers will also be discussed)
o Optical sensors (comprehensive review of the various sensing strategies for optical detection of the above-mentioned biomarkers starting with a list a criteria required in terms on sensitivity and specificity)
o Electrochemical sensors (comprehensive review of the various sensing strategies for electrochemical detection of the above-mentioned biomarkers also highlighting the advantages and drawbacks when compared to optical sensors)
o Device engineering (case studies including description of the main devices/products based on some of the above mentioned sensing technologies that are either already on the market or hold great promise)
• Chapter 2: Imaging
o Optical imaging (comprehensive review of the main optical imaging technologies and their applications for cancer diagnosis and monitoring disease progression or response to treatment)
o Ultrasound imaging (comprehensive review of the advantages and drawbacks of optical imaging and of the most recent advances, e.g. using engineered contrast agents)
o Magnetic Resonance Imaging (comprehensive review of the main MRI techniques applied to cancer diagnosis and monitoring
• Chapter 3: Cancer Therapy
o Nanotechnology (definition of a new, fast growing field, including the role of nanoparticles and biomaterials. Success stories of doxil and abraxane, the first nanotechnology-based cancer drugs that made it to the market)
o Radiotherapy (principles of radiotherapy and recent advances including proton beam therapy)
o Immunotherapy (principles of immunotherapy, new field of immunoengineering recent applications/successes, role of biomaterials in immunotherapy)
o Drug delivery (Reduce side-effects via improved formulations and specific targeting. Recent examples of nano-carriers and new technologies for passive and active targeting)
o Robotic surgery (Recent advances in robotics applied to treatment of cancer)
• Chapter 4: In vitro models
o In-vitro models for Cancer (comprehensive review of the various types of in vitro models for cancer and their applications, e.g. for drug testing)
o Tissue engineering (from 2D to 3D cancer models)
o Biomechanics of cancer cells (comprehensive review of the recent technology for tracking the biomechanics of cancer cells, e.g. cell migration, using 3D in vitro models.
• Conclusion

ISBN: 9780128138861

Page Count: 393

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Bioengineering undergraduate students, Bioengineering postgraduate students (Master and PhD level), Bioengineering academic researchers (RA, PDRA…)