Purchase textbook

New Edition

Protein NMR Spectroscopy,

Edition 2 Principles and Practice

Editors: By John Cavanagh, Nicholas J. Skelton, Wayne J. Fairbrother, Mark Rance and Arthur G. Palmer, III

Publication Date: 20 Nov 2006

0 Reviews

Ways Of Reading

This e-publication is accessible to the full extent that the file format and types of content allow, on a specific reading device, by default, without necessarily including any additions such as textual descriptions of images or enhanced navigation.

Navigation

The contents of the PDF have been tagged to permit access by assistive technologies as per PDF-UA-1 standard.
Page breaks included from the original print source

Additional Accessibility Information

All (or substantially all) textual matter is arranged in a single logical reading order (including text that is visually presented as separate from the main text flow, e.g., in boxouts, captions, tables, footnotes, endnotes, citations, etc.). Non-textual content is also linked from within this logical reading order. (Purely decorative non-text content can be ignored).
The language of the text has been specified (e.g., via the HTML or XML lang attribute) to optimise text-to-speech (and other alternative renderings), both at the whole document level and, where appropriate, for individual words, phrases or passages in a different language.

Conformance

The publication was certified on 20250710
Accessibility addendum
For detailed accessibility information, see Elsevier’s website at https://www.elsevier.com/about/accessibility
For queries regarding accessibility information, contact [email protected]

Note

This product relies on 3rd party tooling which may impact the accessibility features visible in inspection copies. All accessibility features mentioned would be present in the purchased version of the title.

Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution.

Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.

Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.

The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.

Key Features

Provides an understanding of the theoretical principles important for biological NMR spectroscopy
Demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments
Allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics
Includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods

About the author

By John Cavanagh, North Carolina State University, Department of Molecular & Structural Biology, Raleigh, NC, USA; Nicholas J. Skelton, Genentech, Inc., San Francisco, CA, USA; Wayne J. Fairbrother, Genentech, Inc., San Francisco, CA, USA; Mark Rance, University of Cincinnati, Cincinnati, OH, USA and Arthur G. Palmer, III, Columbia University, New York, NY, USA

PREFACE

PREFACE TO THE FIRST EDITION

ACKNOWLEDGEMENTS

Chapter 1: CLASSICAL NMR SPECTROSCOPY

Chapter 2: THEORETICAL DESCRIPTION OF NMR SPECTROSCOPY

Chapter 3: EXPERIMENTAL ASPECTS OF NMR SPECTROSCOPY

Chapter 4: MULTIDIMENSIONAL NMR SPECTROSCOPY

Chapter 5: RELAXATION AND DYNAMIC PROCESSES

Chapter 6: EXPERIMENTAL ¹H NMR METHODS

Chapter 7: HETERONUCLEAR NMR EXPERIMENTS

Chapter 8: EXPERIMENTAL NMR RELAXATION METHODS

Chapter 9: LARGER PROTEINS AND MOLECULAR INTERACTIONS

Chapter 10: SEQUENTIAL ASSIGNMENT, STRUCTURE DETERMINATION, AND OTHER APPLICATIONS

TABLE OF SYMBOLS

LIST OF FIGURES

LIST OF TABLES

Title Reviews

"This volume is a comprehensive introduction to the methodology required for NMR studies of proteins."—JOURNAL OF MAGNETIC RESONANCE

"Protein NMR Spectroscopy: Principles and Practice covers a huge range of topics related to NMR....A fine two-semester course could be built on this very thorough book. Any student currently using NMR could benefit from the Cavanagh et al. text, which provides an in-depth explanation that is suitable as a resource for even a knowledgeable spectroscopist."—NATURE STRUCTURAL BIOLOGY

"All in all, I find the book very, very good. It will fill an important void in the literature/material available in the NMR field.....There are many 'hands on' secrets that will be very valuable to those beginning in the field as well as those who are 'old hands.' It has a distinct advantage over other books in that is was written as a whole, freshly from cover to cover; it is NOT a collection of published articles hurriedly put together with a nice binding."—DALE F. MIERKE, UNIVERSITY OF MASSACHUSETTS, AMHERST

"Along with detailed explanations of the mechanisms underlying the modern NMR experiments, the book also brings some "order"to the bewildering array of novel NMR pulse sequences. To practitioners of biomolecular NMR, it will prove invaluable for years to come."—STRUCTURE

ISBN: 9780121644918

Page Count: 912

Retail Price (USD) :

Becker: High Resolution NMR, 3e (Oct 1999, ISBN-10/13: 0-12-084662-4/ 978-0-12-084662-7)
Rahman and Choudhary: Solving Problems with NMR Spectroscopy (Dec 1995, ISBN-10/13: 0-12-066320-1/ 978-0-12-066320-0)
Rhodes: Crystallography Made Crystal Clear, 2e (Nov 1999, ISBN-10/13: 0-12-587072-8/ 978-0-12-587072-6)

Protein NMR Spectroscopy,

Editors: By John Cavanagh, Nicholas J. Skelton, Wayne J. Fairbrother, Mark Rance and Arthur G. Palmer, III

Description

Key Features

About the author

Title Reviews

Related Titles