Book Details

1. Introduction
1.1 Drug Delivery and Drug Delivery Systems
1.2 The Promise of Novel Drug Delivery Systems
1.3 The Layout of the Textbook
1.4 Resources for Studying Drug Delivery
Lab Activity I: Delivery of nucleic acids into Cells Using Cationic Lipids
Review and Practice Questions
References

2. Historical Aspects of Pharmacy and Delivery of Drugs
2.1 Historical Aspects of Drugs, Pharmacy, and Pharmacy Education
2.2 Historical Aspects of Drug Delivery
Review and Practice Questions
References

3. Basics of Pharmacology, Pharmacokinetics and Pharmacodynamics
3.1 Introduction to Pharmacology, Pharmacokinetics and Pharmacodynamics
3.2 Drug Actions on Living Organisms
3.3 Termination of Drug Actions: Excretion and Biotransformation
3.4 Pharmacokinetics
3.5 Factors Influence the Drug Effects
Case Study I
Lab Activity II: Drug Stability
Review and Practice Questions
References

4. Physiological and Biochemical Barriers to Drug Delivery
4.1 Process of Drug Absorption
4.2 Physiological Barriers to Peroral Drug Delivery
4.3 First-pass metabolism
4.4 Physiological Barriers to Non-peroral Drug Delivery
4.5 Biochemical Barriers to Drug Delivery
4.6 Immune System and Drug Delivery Systems
4.7 Novel Models for Drug Testing
Case Study II
Sample and Practice Questions
References

5. Prodrugs as Drug Delivery Systems
5.1 Introduction to Prodrugs
5.2 Principles of Prodrug Design
5.3 Advances in Prodrugs as Drug Delivery Systems
5.4 New Prodrugs in Therapy
Case Study III
Review and Practice Questions
References

6. Engineered Carriers in Drug Delivery
6.1 Materials for Drug Carriers
6.2 Microscale Drug Carriers
6.3 Nanoscale Drug Carriers
6.4 Design and Modify Drug Carriers
Lab Activity III: Natural Biopolymer Purification
Lab Activity IV: Microscale Carrier Preparation: Hydrogel Microspheres
Lab Activity V: Nanoscale Carrier Preparation: Metallic Nanoparticles
Review and Practice Questions
References

7. Cell Encapsulation – A Living Drug Delivery Approach
7.1 Introduction to Cell Encapsulation and Microencapsulation
7.2 Cell Microencapsulation Methods
7.3 Cell Encapsulation in Therapy
Case Study IV
Lab Activity VI: Cell (Micro)Encapsulation in Hydrogel
Review and Practice Questions
References

8. Diffusion-Controlled Drug Delivery Systems
8.1 Diffusion Theory
8.2 Reservoir Systems
8.3 Matrix Systems
8.4 Design of Diffusion-Controlled Drug Delivery Systems
Review and Practice Questions
References

9. Erodible Drug Delivery Systems
9.1 Introduction to Erosion
9.2 Drug Release from the Erodible Drug Delivery Systems
9.3 Design of Erodible Drug Delivery Systems
Lab Activity VII: Drug Release Profile Determination
Review and Practice Questions
References

10. Osmotic-Controlled Drug Delivery Systems
10.1 Osmosis
10.2 Elementary Osmotic-Controlled Drug Delivery Systems
10.3 Push-Pull Systems
10.4 Design of Osmotic-Controlled Drug Delivery Systems
Case Study V
Review and Practice Questions
References

11. Targeted Drug Delivery Systems
11.1 Requirements for Effective Drug Targeting
11.2 Design of Targeted Drug Delivery Systems: Targets and Ligands
11.3 Design of Targeted Drug Delivery Systems: Physical Targeting
11.4 Design of Targeted Drug Delivery Systems: Passive and Active Targeting
Review and Practice Questions
References

12. Biomimetic Drug Delivery Systems
12.1 Biomimicry
12.2 Cell Membrane/Lipoprotein-Based Drug Delivery Systems
12.3 Extracellular Vesicles-Based Drug Delivery Systems
12.4 Design of Biomimetic Drug Delivery Systems
Review and Practice Questions
References

13. Site-Specific Drug Delivery
13.1 Drug Delivery to the Brain
13.2 Drug Delivery to the Colon
13.3 Drug Delivery in Cancer Therapy
Review and Practice Questions
References

14. Stimuli-Responsive Drug Delivery Systems
14.1 Internal and External Stimuli
14.2 pH-Responsive Drug Delivery Systems
14.3 Redox-Responsive Drug Delivery Systems
14.4 Enzyme-Responsive Drug Delivery Systems
14.5 External Stimuli-Based Drug Delivery Systems
14.6 Design of Stimuli-Responsive Drug Delivery Systems
Case Study VI
Lab Activity VII: Stimuli-Responsive Drug Carriers
Review and Practice Questions
References

15. Other Drug Delivery Systems
15.1 Mucoadhesive Drug Delivery Systems
15.2 Micro Nozzle Technology-Based Drug Delivery Systems
15.3 Microrobots-Based Drug Delivery Systems
15.4 Engineered Cells as Drug Delivery Systems
15.5 Wireless On-Demand Drug Delivery Systems
15.6 3D Printing-Based Drug Delivery Technology
15.7 Artificial Intelligence (AI) in Drug Delivery
Review and Practice Questions
References

16. Commercialization of Controlled Release Products
16.1 Implementation of Quality by Design (QbD), Design of Experiments (DoE) and Process Analytical Technology (PAT)
16.2 New Drug Development and Approval Process
16.3 Recalls, Market Withdraws, and Safety Alerts
Review and Practice Questions
References